The burden of side effects contributes to noncompliance and reduction of quality of life.Depixol Injection: 20 mg/ml flupentixol decanoate in thin vegetable oil. Injection: 100 mg/ml flupentixol decanoate in thin vegetable oil.Antipsychotic medicines are classified as “typical” or “atypical”.
• Side effects differ between first- and second-generation antipsychotics.
Khan is research scientist at the Manhattan Psychiatric Center on Ward’s Island, New York. Please direct all correspondence to: Jean-Pierre Lindenmayer, MD, Clinical Director, Manhattan Psychiatric Center, 600 E 125th St, Ward’s Island, NY 10035; Tel: 646-672-6767, ext. • Antipsychotic side effects significantly contribute to noncompliance and reduction of quality of life.
Patients taking Clozaril must have blood tests done every week for at least the first six months of therapy.
Only 7 to 14 days of medication are dispensed at one time, and only if blood tests indicate that it is safe to continue Clozaril therapy.
Antipsychotics are indicated for the treatment of schizophrenia and related disorders and in some circumstances to treat the behavioural and psychological symptoms associated with dementia (risperidone only).
Antipsychotics are not a first-line treatment for anxiety and are not recommended for post-traumatic stress disorder or insomnia.
Atypical antipsychotics, also known as second generation antipsychotics, include quetiapine, risperidone and olanzapine.
Both types of antipsychotics act in a similar way by blocking receptors in the dopamine pathway, but atypical antipsychotics are less likely to cause the extrapyramidal adverse effects associated with the older typical antipsychotics.
Khan report no affiliation with or financial interest in any organization that may pose a conflict of interest. Lindenmayer is a consultant to Janssen; and receives grant support from Astra Zeneca, Avanir, Bristol-Myers Squibb, Eli Lilly, the National Institute of Mental Health, and Pfizer.