It remained popular even after 99m Technetium based tracers became available for single-day imaging protocols, viability studies, or in conjunction with 99m Tc tracers in ‘hybrid’ dual-isotope protocols.It was common to do resting Thallium perfusion imaging, followed by 99m Tc-sestamibi gated SPECT stress imaging, combining the best characteristics of both radiopharmaceuticals.
When the supply of 99m Technetium became unavailable from vendors, old-standby Thallium protocols kept Nuclear Cardiology labs open for business without missing a beat.
Thallium imaging is historically significant as the epitome of myocardial perfusion imaging for decades, becoming a sort of ‘gold standard’ for its time.
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